Pesquisa sobre: AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG 
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Descritor Inglês:   Autophagy-Related Protein-1 Homolog 
Descritor Espanhol:   Homólogo de la Proteína 1 Relacionada con la Autofagia 
Descritor Português:   Proteína Homóloga à Proteína-1 Relacionada à Autofagia 
Sinônimos Inglês:   Serine-Threonine Protein Kinase ULK1
ULK1 Protein
Unc-51 Like Autophagy Activating Kinase 1
Unc-51-Like Kinase 1
Autophagy Related Protein 1 Homolog
Serine Threonine Protein Kinase ULK1
Unc 51 Like Autophagy Activating Kinase 1
Unc 51 Like Kinase 1  
Categoria:   D08.811.913.696.620.682.700.108
D12.644.360.081
D12.776.094.438
D12.776.476.078
Definição Inglês:   A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates. 
Nota Histórica Inglês:   2017 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   56509 
Identificador Único:   D000071189 

Ocorrência na BVS:
 

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